Prof. Padmaja Prasad Mishra

Research

SINGLE MOLECULE BIOPHYSICS:- At the interface between chemistry, physics and biology, single-molecule biophysics is essential in the elucidation of modern biological questions. This technique is regarded as a combination of science and the engineering, overcomes the limitations originated from averaging inherent in experiments of bulk samples. A predomination of single-molecule experiments lies in its ability to extract valuable molecular information (structure, dynamics and function), which are usually hidden when whole sample population is taken under consideration. Our aim is to develop and use single-molecule fluorescence methods to address a number of key issues in molecular biophysics. Direct observation of multiple species, steps, pathways and complex kinetics in Double strand DNA breaks repairing and homogeneous end joining, protein folding and misfolding, etc are the area we wish to work on. Our multidisciplinary research utilizes a broad range of tools from chemistry, biology and physics. Research Interest:- 1. Repair of Double strand DNA Break 2.Non-homologous end-joining of double strand DNA breakage 3.Study of passive ion transportation in self-assembled inorganic capsule membrane 4.Structural Dynamics of transcription termination