Prof. Sampa Biswas

Professor
Room No	:	313
Ext.	:	1313
Email id	:	sampa.biswas[AT]saha.ac.in
Division	:	Crystallography and Molecular Biology Division

Papers in Journals

“Enhancement of proteolytic activity of a thermostable papain-like protease by structure-based rational design” Sruti Dutta, Jiban Kanti Dattagupta and Sampa Biswas. PlosOne (2013) May 3;8(5):e62619.

“Protein interactions of Merocyanine 540: spectroscopic and crystallographic studies with lysozyme as a model protein” Piyali Mitra, Mousumi Banerjee, Sampa Biswas, Samita Basu. Journal of Photochemistry and Photobiology B: Biology (2013) 121 46–56.

“The structure of a thermostable mutant of pro-papain reveals its activation mechanism” Sumana Roy, Debi Choudhury, Pulakesh Aich, Jiban K Dattagupta and Sampa Biswas. Acta Crystallographica- Biological Crystallography (2012) D68, 1591–1603.

“Expression of recombinant human cathepsin K is enhanced by codon optimization" Sumana Roy, J.K. Dattagupta, Sampa Biswas. Process Biochemistry (2012) 47, 1944–1947.

“C-terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism” Sruti Dutta, Debi Choudhury, Jiban Kanti Dattagupta and Sampa Biswas. FEBS Journal (2011) 278, 3012–3024.

“Crystallization and preliminary X-ray diffraction studies of the precursor protein of a thermostable variant of papain” Sumana Roy, Debi Choudhury, Chandana Chakrabarti, Sampa Biswas and J. K. Dattagupta Acta Cryst. (2011) F67, 634–636.

“Improving thermostability of Papain through structure-based protein engineering” Debi Choudhury^#, Sampa Biswas^#, Sumana Roy and J K Dattagupta.   Protein Engineering, Design and Selection (2010) 23, 657-667.

“Heterologous expression of a thermostable plant cysteine protease in Escherichia coli both in soluble and insoluble forms” Sruti Dutta, Raka Ghosh, J.K Dattagupta and Sampa Biswas. Process Biochemistry (2010) 45, 1307-1312.

“Production and recovery of recombinant pro-papain with high yield” Debi Choudhury, Sumana Roy, Chandana Chakrabarti, Sampa Biswas and J.K. Dattagupta. Phytochemistry (2009) 70, 465-472.

“Structural insight into the substrate specificity and activity of Ervatamins: the papain-like cysteine proteases from a tropical plant Ervatamia coronaria” Raka Ghosh, Sibani Chakraborty, Chandana Chakrabarti, Jiban Kanti Dattagupta and Sampa Biswas. FEBS Journal (2008) 275, 421-434.*

“A thermostable cysteine protease precursor from a tropical plant contains an unusual C-terminal propeptide: cDNA cloning, sequence comparison and molecular modeling studies” Raka Ghosh, Jiban K. Dattagupta and Sampa Biswas. Biochemical and Biophysical Research Communications (2007) 62, 965-970.

“Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria” Piyali Guha Thakurta, Sampa Biswas, Chandana Chakrabarti, Monica Sundd, Medicherla V. Jagannadham and Jiban K. Dattagupta. Biochemistry (2004) 43(6) 1532-1540.

“Functional properties of Soybean Nodulin26 from a comparative three dimensional model.” Sampa Biswas. FEBS Lett. (2004) 558, 39-44.

“Proposed Amino Acid Sequence and the 1.63 Å X-ray Crystal Structure of a Plant Cysteine Protease, Ervatamin B: Some Insights into the Structural Basis of its Stability and Substrate Specificity” Sampa Biswas, Chandana Chakrabarti, Suman Kundu, Medicherla V. Jagannadham and Jiban K Dattagupta. Proteins: Structure, Function, and Genetics (2003) 51 (4), 489 -497.

“Purification and preliminary X-ray studies of hen sero-transferrin in apo- and holo- forms.” Debi choudhury, Piyali Guha Tharkurta, Rakhi Sengupta, U. Sen, S. Biswas, C. Chakrabarti and J. K. Dattagupta. Biochemical and Biophysical Research Communications. 295 (2002), 125 –128.

“Crystallization and preliminary X-ray analysis of ervatamin B and C, two thiol proteases from Ervatmia coronaria. “ Chandana Chakraborty, Sampa Biswas, Suman Kundu, Monica Sundd, J. V. Medicherla and Jiban Kanti Dattagupta. Acta. Cryst.1999 D55, 1074-1075.

“A stacked Pyrazolo[3,4-d]pyrimidine-based Flexible Molecule” , Prakash Maulik, K. Avasthi, Goutam Biswas, Sampa Biswas, D.S. Rawat, S. Sarkhel, Tilak Chandra and D. S. Bhakuni. Acta Cryst. 1998 C54, 275-277.

"Crystal structure of 3,4-dihydro-4[(1-cyclohexenyl) nitro-methyl[-3-nitro-2-(3,4-methylenedioxyphenyl-2H- ........." , S.Biswas, P.R.Maulik, R.C.Gupta, M.Seth, A.P. Bhadury. Acta Cryst. 1996 C52, 1032-1038.

"Tropinyl 2-isopropylbenzo[b]thiophene-3-carboxylate", B.C.Das, S.Pain (Biswas), G. Biswas, S.N.Ganguly and Asok Banerjee. Acta Cryst . 1995 C51, 2386-2388.

"Studies on organometallic compounds: An approach towards characterisation of structure and activity of triorganostanyl    2-(arylazo) benzenecarboxylates in relation to bacterial cell wall" B.B.Maji, S. Pain, G. Biswas, K. L. Ghatak, S.N.Ganguly and Asok Banerjee. Proc. Indian Acad. Sci.(Chem. Sci). 1993, 105, No.-3, 183-187.

"Crystal structure of N-(4-nitrophenyl) -N-phenylsulfonamide" A. C. Gomes, G. Biswas, S. Biswas (Pain), G.K.Biswas, Y.Iitaka and Asok Banerjee. J. Cryst. and Spectroscopic Res. 1993, 23, No.-6, 513 -517.

"Structure of a Modified beta-lactam analogue" Sampa Pain, Goutam Biswas, Ajoy Bose and Asok Banerjee. Acta Cryst. 1992.   C48, 666-669.

"On structural aspects of peptidoglycan of bacterial cell wall with special attention on Mycobacteria by computer   modelling" S. Pain, A. Bera, M. Das, B. N. Das and A. Banerjee. Indian J. Lepr. 1992. 64(1), 28-41.

"Structure of a modified beta-lactam antibiotic" Sampa Pain, Goutam Biswas, Asok Banerjee, A. De, A. Mathur, A. Bose and Y. Iitaka. Acta Cryst. 1991. C47, 360-362.

"Chemically modified analogs of antiviral nucleoside- a review for understading Structure- activity relation" Goutam Biswas, Indrani Dey, Sampa Pain and Asok Banerjee. Trans. Bose Res. Inst. 1990. 53(2-3), 43-60.

"Conformational analysis of some medically important arabinonucleosides with special attention on conformations of furanose moeity" Goutam Biswas, Sampa Pain, B. N. Das and Asok Banerjee. Indian J. Phys. 1989. 63A(4), 355-360.

Education

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Papers in Journals

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Papers in Journals
“Enhancement of proteolytic activity of a thermostable papain-like protease by structure-based rational design” Sruti Dutta, Jiban Kanti Dattagupta and Sampa Biswas. PlosOne (2013) May 3;8(5):e62619. “Protein interactions of Merocyanine 540: spectroscopic and crystallographic studies with lysozyme as a model protein” Piyali Mitra, Mousumi Banerjee, Sampa Biswas, Samita Basu. Journal of Photochemistry and Photobiology B: Biology (2013) 121 46–56. “The structure of a thermostable mutant of pro-papain reveals its activation mechanism” Sumana Roy, Debi Choudhury, Pulakesh Aich, Jiban K Dattagupta and Sampa Biswas. Acta Crystallographica- Biological Crystallography (2012) D68, 1591–1603. “Expression of recombinant human cathepsin K is enhanced by codon optimization" Sumana Roy, J.K. Dattagupta, Sampa Biswas. Process Biochemistry (2012) 47, 1944–1947. “C-terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism” Sruti Dutta, Debi Choudhury, Jiban Kanti Dattagupta and Sampa Biswas. FEBS Journal (2011) 278, 3012–3024. “Crystallization and preliminary X-ray diffraction studies of the precursor protein of a thermostable variant of papain” Sumana Roy, Debi Choudhury, Chandana Chakrabarti, Sampa Biswas and J. K. Dattagupta Acta Cryst. (2011) F67, 634–636. “Improving thermostability of Papain through structure-based protein engineering” Debi Choudhury^#, Sampa Biswas^#, Sumana Roy and J K Dattagupta. Protein Engineering, Design and Selection (2010) 23, 657-667. “Heterologous expression of a thermostable plant cysteine protease in Escherichia coli both in soluble and insoluble forms” Sruti Dutta, Raka Ghosh, J.K Dattagupta and Sampa Biswas. Process Biochemistry (2010) 45, 1307-1312. “Production and recovery of recombinant pro-papain with high yield” Debi Choudhury, Sumana Roy, Chandana Chakrabarti, Sampa Biswas and J.K. Dattagupta. Phytochemistry (2009) 70, 465-472. “Structural insight into the substrate specificity and activity of Ervatamins: the papain-like cysteine proteases from a tropical plant Ervatamia coronaria” Raka Ghosh, Sibani Chakraborty, Chandana Chakrabarti, Jiban Kanti Dattagupta and Sampa Biswas. FEBS Journal (2008) 275, 421-434.* “A thermostable cysteine protease precursor from a tropical plant contains an unusual C-terminal propeptide: cDNA cloning, sequence comparison and molecular modeling studies” Raka Ghosh, Jiban K. Dattagupta and Sampa Biswas. Biochemical and Biophysical Research Communications (2007) 62, 965-970. “Structural basis of the unusual stability and substrate specificity of ervatamin C, a plant cysteine protease from Ervatamia coronaria” Piyali Guha Thakurta, Sampa Biswas, Chandana Chakrabarti, Monica Sundd, Medicherla V. Jagannadham and Jiban K. Dattagupta. Biochemistry (2004) 43(6) 1532-1540. “Functional properties of Soybean Nodulin26 from a comparative three dimensional model.” Sampa Biswas. FEBS Lett. (2004) 558, 39-44. “Proposed Amino Acid Sequence and the 1.63 Å X-ray Crystal Structure of a Plant Cysteine Protease, Ervatamin B: Some Insights into the Structural Basis of its Stability and Substrate Specificity” Sampa Biswas, Chandana Chakrabarti, Suman Kundu, Medicherla V. Jagannadham and Jiban K Dattagupta. Proteins: Structure, Function, and Genetics (2003) 51 (4), 489 -497. “Purification and preliminary X-ray studies of hen sero-transferrin in apo- and holo- forms.” Debi choudhury, Piyali Guha Tharkurta, Rakhi Sengupta, U. Sen, S. Biswas, C. Chakrabarti and J. K. Dattagupta. Biochemical and Biophysical Research Communications. 295 (2002), 125 –128. “Crystallization and preliminary X-ray analysis of ervatamin B and C, two thiol proteases from Ervatmia coronaria. “ Chandana Chakraborty, Sampa Biswas, Suman Kundu, Monica Sundd, J. V. Medicherla and Jiban Kanti Dattagupta. Acta. Cryst.1999 D55, 1074-1075. “A stacked Pyrazolo[3,4-d]pyrimidine-based Flexible Molecule” , Prakash Maulik, K. Avasthi, Goutam Biswas, Sampa Biswas, D.S. Rawat, S. Sarkhel, Tilak Chandra and D. S. Bhakuni. Acta Cryst. 1998 C54, 275-277. "Crystal structure of 3,4-dihydro-4[(1-cyclohexenyl) nitro-methyl[-3-nitro-2-(3,4-methylenedioxyphenyl-2H- ........." , S.Biswas, P.R.Maulik, R.C.Gupta, M.Seth, A.P. Bhadury. Acta Cryst. 1996 C52, 1032-1038. "Tropinyl 2-isopropylbenzo[b]thiophene-3-carboxylate", B.C.Das, S.Pain (Biswas), G. Biswas, S.N.Ganguly and Asok Banerjee. Acta Cryst . 1995 C51, 2386-2388. "Studies on organometallic compounds: An approach towards characterisation of structure and activity of triorganostanyl 2-(arylazo) benzenecarboxylates in relation to bacterial cell wall" B.B.Maji, S. Pain, G. Biswas, K. L. Ghatak, S.N.Ganguly and Asok Banerjee. Proc. Indian Acad. Sci.(Chem. Sci). 1993, 105, No.-3, 183-187. "Crystal structure of N-(4-nitrophenyl) -N-phenylsulfonamide" A. C. Gomes, G. Biswas, S. Biswas (Pain), G.K.Biswas, Y.Iitaka and Asok Banerjee. J. Cryst. and Spectroscopic Res. 1993, 23, No.-6, 513 -517. "Structure of a Modified beta-lactam analogue" Sampa Pain, Goutam Biswas, Ajoy Bose and Asok Banerjee. Acta Cryst. 1992. C48, 666-669. "On structural aspects of peptidoglycan of bacterial cell wall with special attention on Mycobacteria by computer modelling" S. Pain, A. Bera, M. Das, B. N. Das and A. Banerjee. Indian J. Lepr. 1992. 64(1), 28-41. "Structure of a modified beta-lactam antibiotic" Sampa Pain, Goutam Biswas, Asok Banerjee, A. De, A. Mathur, A. Bose and Y. Iitaka. Acta Cryst. 1991. C47, 360-362. "Chemically modified analogs of antiviral nucleoside- a review for understading Structure- activity relation" Goutam Biswas, Indrani Dey, Sampa Pain and Asok Banerjee. Trans. Bose Res. Inst. 1990. 53(2-3), 43-60. "Conformational analysis of some medically important arabinonucleosides with special attention on conformations of furanose moeity" Goutam Biswas, Sampa Pain, B. N. Das and Asok Banerjee. Indian J. Phys. 1989. 63A(4), 355-360.

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Prof. Sampa Biswas